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    2016年3月1日
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    2016年8月31日
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    2016年9月9日
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    2016年9月10日
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    2016年9月25日
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大会议程

Eighth International Conference SUMO, Ubiquitin, UBL Proteins:
Implications for Human Diseases

会议时间: 2016年10月21-23日
会议地点: 重庆南路227号,上海交通大学医学院, 懿德楼二楼报告厅

 

Friday, Oct. 21, 2016
7:30 a.m.   Registration
8:00 – 8:30 a.m.   Welcome
Guo-Qiang Chen
Shanghai Jiao Tong University, Shanghai, China
Edward T.H. Yeh
University of Missouri School of Medicine, Columbia, MO, USA
Jinke Cheng
Shanghai Jiao Tong University, Shanghai, China
8:30–10:10 a.m.   Session I
Moderator: Guo-Qiang Chen
Shanghai Jiao Tong University, Shanghai, China
8:30 –8:55 — Monoubiquitination as a Novel Proteasomal Degradation Signal:  Mechanistic and Biomedical Implications
Aaron Ciechanover
Technion-Israel Institute of Technology, Haifa, Israel
8:55-9:20 —WDR4-driven PML ubiquitination fosters immunosuppressive and pro-metastatic lung tumor microenvironment
Ruey-Hwa Chen
Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
9:20-9:45 — FBXW7 facilitates NHEJ repair by promoting XRCC4 ubiquitylation: potential therapeutic application
Yi Sun
Zhejiang University, Hangzhou, China
9:45 - 10:10— Cell cycle dependent regulation of the REGγ proteasome function
Xiaotao Li
East China Normal University, Shanghai, China

10:10-10:30 a.m.   Break
10:30 a.m.-12:00 p.m. Session II
Moderator: Edward T.H. Yeh
Department of Medicine, University of Missouri, Columbia MO, USA
10:30-10:55— Mechanisms of regulation of APC/C ubiquitin ligase in the cell cycle
Avram Hershko
Technion-Israel Institute of Technology, Haifa, Israel
10:55-11:20— Interplay between ubiquitylation and protein methylation in genome stability and tumorigenes
Yong Wan
University of Pittsburgh, Pittsburgh, PA
11:20-11:45 — Protein Ubiquitination in Inflammation Control
Jianping Jin
University of Texas McGovern Medical School at Houston, Houston, TX
11:45-12:00 —Control of breast cancer metastasis by ubiquitin-mediated signaling
Xuefeng Wu
Shanghai Jiao Tong University, Shanghai, China

12:00 noon -1:00 p.m.   Lunch
1:00 - 2:30 p.m.   Session III
Moderator: Hsiu-Ming Shih
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

1:00 - 1:25 — Novels insights into the relationship between SUMO and PML
Hugues de Thé
University of Paris, Paris, France

1:25-1:50 — The role and mechanism for regulation of global transcription by SUMO
Jiemin Wong
East China Normal University, Shanghai, China

1:50-2:15— SAE activator and SERCA2A/heart failure
Changwon Kho
Icahn School of Medicine at Mount Sinai

2:15-2:30— SUMOylation regulates microRNA biogenesis and efficiency
Jianxiu Yu
Shanghai Jiao Tong University, Shanghai, China
2:30-2:50 p.m.   Break
2:50 - 4:20 p.m.   Session IV
Moderator: Hughes de The
University of Paris, Paris, France
2:50- 3:15 — A death-promoting SIM peptide
Edward T.H. Yeh
Department of Medicine, University of Missouri, Columbia MO, USA
3:15- 3:40 — SUMOYlation in adipocytes and metabolic disorders
Lan Shao
Yale University, New Haven, CT
3:40 - 4:05— Sirt3 SUMOylation and mitochondrial metabolism
Jinke Cheng
Shanghai Jiao Tong University, Shanghai, China
4:05 - 4:20— Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer
Chenji Wang
Fudan University, Shanghai, China
4:20 - 4:40 p.m.   Break
4:40 – 6:20 p.m.   Session V
Moderator: Min Wang
Yale University, New Haven, CT
4:40 - 5:05 —Interdependence of SENP-nucleoporin association for control of the SUMO pathway
Mary Dasso
National Institutes of Health, LGRD, NICHD, Bethesda, Maryland
5:05 - 5:30 —SENP3 in the control of ribosome biogenesis and gene expression programs
Stefan Muller
Johann Wolfgang Goethe University, Frankfurt am Main, Germany
5:30 - 5:55 —Reversible SUMOylation regulates autophagy in a fine-tuning manner
Jing Yi
Shanghai Jiao Tong University, Shanghai, China
5:55 – 6:20 —SENP7 Isoforms Direct Tumorigenesis in Mammary Epithelia
Tasneem Bawa-Khalfe
University of Houston, Houston, TX
6:20-6:30 p.m.   Break
6:30- 9:15 p.m.   Session VI   Poster Session and Dinner
Saturday, Oct 22, 2016
7:30 a.m.   Registration
8:30-10:00 a.m.   Session VII
Moderator: Yong Wan
University of Pittsburgh, Pittsburgh, PA
8:30-8:55 — Roles of Protein SUMOylation in the Replication Stress Response
Zou Lee
Harvard Medical School,Charlestown, MA
8:55-9:20— The SUMO system controls T cell synapse organization and T cell activation
Yingqiu Li
Sun Yat-sen University,Guangzhou, China
9:20-9:45— Sumoylation of RAS is essential for its oncogenic activation
Wei Dai
New York University, New York, NY
9:45-10:00— Chemotherapeutic drugs rapidly alter transcriptional programs in Acute Myeloid Leukemia via the ROS/SUMO pathway
Guillaume Bossis
CNRS- IGMM, Montpellier, France
10:00-10:20 a.m.   Break
10:20 a.m. – 12:05 p.m.  Session VIII
Moderator: Bing Su
Shanghai Jiao Tong University, Shanghai, China
10:20-10:45— Control of regulatory T cells by the ubiquitin pathway
Yuncai Liu, Tsinghua University, Beijing, China
10:45-11:10— Regulation of Immunity and Tumorigenesis by Deubiquitinases
Shao-Cong Sun
The University of Texas MD Anderson Cancer Center, Houston, TX
11:10-11:35— The novel mechanisms by which spermtoproteasomes regulates spermatogenessis
Xiaobo Qiu
Beijing Normal University, Beijing, China
11:35-11:50— RIG-I activation by ubiquitination in antiviral innate immune signaling
Fajian Hou
Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
11:50-12:05—Optimizing TRAF6 Ubiquitin Ligase Processivity via Oligomerization-primed Coiled-Coil Domain Interaction with Ubc13 is Essential for TAK1 Activation
Zongping Xia
Zhejiang University, Hangzhou, China

12:05 – 1:15 p.m.  Lunch
1:15-2:50p.m.  Session IX
Moderator: Ruey-Hwa Chen
Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

1:15-1:40— Regulation of Innate Immune Signaling by ER Ubiquitin Ligase AMFR
Chen Wang
Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
1:40-2:05— The E3 ligase HECTD3 promotes cancer cell survival  by targeting and inhibiting caspase-9 activation
Zhihua Liu
Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2:05-2:20—The E3 ligase SMURF2 regulates bone homeostasis by disrupting VDR/SMAD3 interaction in osteoblasts
Weiguo Zou
Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
2:20-2:35—Triggering Proteasomal degradation of HMGB1 by Lycorine Induces Autophagy Inhibition and Enhances Bortezomib Activity in Multiple Myeloma
Mridul Roy
Central South University, Changsha, China
2:35-2:50— The APC/C-Cdh1-Borealin axis has critical role in the maintenance of undifferentiated state in embryonal carcinoma cells
Kudo Yasusei
Tokushima University, Tokushima, Japan
2:50-3:10 p.m.   Break
3:10-4:30 p.m.   Session X
Moderator: Ceshi Chen
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
3:10-3:35— hCINAP, a novel regulator of ubiquitin-like protein modifications in various signaling pathways, is essential for tumor growth
Xiaofeng Zheng
Peking University, Beijing, China
3:35-4:00— Targeting overactivated neddylation pathway for anticancer therapy
Lijun Jia
Fudan University, Shanghai, China
4:00-4:15— GSK3beta- and Fbw7beta-dependent Proteolysis of the Methyltransferase SETD3 Regulates Cell Cycle Progression and Suppresses Liver Tumorigenesis
Hai-Ning Du
Wuhan University, Wuhan, China
4:15-4:30—Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility
Xu Tan
Tsinghua University, Beijing, China
4:30-4:45—Crosstalk between neddylation and ubiquitylation mediated by inositol hexakisphosphate (IP6)
Feng Rao
South University of Science and Technology of China, Shenzhen, China
4:45-5:00—ITIM Receptors and Leukemia
Xunlei Kang
University of Missouri School of Medicine, Columbia, MO, USA

Sunday, Oct 23, 2016
7:30 a.m.   Registration
8:30-10:05 a.m.   Session XI
Moderator: Mary Dasso
National Institutes of Health, LGRD, NICHD, Bethesda, Maryland

8:30-8:55—Association of the SENP2 SUMO isopeptidase with intracellular membranes
Michael Matunis
Johns Hopkins University, Baltimore, MD

8:55-9:20Regulation of SUMO modification in breast cancer
Hsiu-Ming Shih
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
9:20-9:45— Nuclear receptor Nur77 attenuates PEPCK1 sumoylation to suppress hepatocellular carcinoma via switching glucose metabolism
Qiao Wu
Xiamen University, Xiamen, China
9:45-10:00—Influenza A virus interplays with the host sumoylation system for virus replication
Ke Xu
Institute Pasteur of Shanghai, Chinese Academy of Sciences, China
10:10-10:20 a.m.   Break
10:20 a.m.-12:05 p.m.   Session XII
Moderator: Peter Zhou
University of Kentucky, Lexington, KY

10:20-10:45— Protein stability regulators screening assay (Pro-SRSA): protein degradation meets the CRISPR-Cas9 library
Tiebang Kang
Sun Yat-sen University, Guangzhou, China
10:45-11:10 —Ubiquitylation of autophagy receptors: multiple modes of regulation on cellular autophagic flux
Ronggui Hu
Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
11:10-11:35— Molecular regulation of receptor-mediated mitophagy and its implication in diseases
Quan Chen
Institute of Zoology, Chinese Academy of Sciences, China
11:35-11:50— Regulation of the differentiated cell identity by aUb/UbL network
Amir Orian
Technion, Faculty of Medicine, Haifa, Israel
11:50-12:05 —In vivo sumoylation control by PML nuclear bodies under oxidative stress
Sarah Tessier
University of Paris, Paris, France
12:05-1:10 p.m.   Lunch
1:10-3:05 p.m.    Session XIII
Moderator: Tiebang Kang
Sun Yat-sen University, Guangzhou, China
1:10-1:35 — STAT3 ubiquitination and acetylation in unclear niche
Eugene Chin
Institute for Health Sciences, Chinese Academy of Sciences, Shanghai, China
1:35-2:00 — Regulation of Ubiquitination and De-ubiquitination of Snail in Breast Cancer Progression and Metastasis
Binhua Zhou
University of Kentucky, Lexington, KY
2:00-2:25 — BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5
Ceshi Chen
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China

2:25-2:50— p38 inhibition provides anti-DNA virus immunity by regulation of USP21bphosphorylation and STING activation
Ping Wang
Tongji University, Shanghai, China
2:50-3:05 —Sequestration of Ubiquitin-Related Proteins by PolyQ Aggregates
Hong-Yu Hu
Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China


3:05 -3:30 p.m.   Break
3:30-4:50p.m.   Session XIV
Moderator: Eugene Chin
Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

3:30-3:55Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal and the development of SUMOylation inhibitors
Yuan Chen
Beckman Research Institute of the City of Hope, Duarte, CA

3:55-4:20—GATA5 sumolation is indispensible for zebrafish cardiac development
Jun Zhu
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China
4:20-4:35The critical role of SENP1-mediated GATA2 deSUMOylation in graft arteriosclerosis by promoting endothelial activation
Luyang Yu
Zhejiang University, Hangzhou, China
4:35-4:50 —Efficient Enrichment of SUMOylated Peptides from Alpha-lytic Protease Digest Using K- Ɛ -GG Remnant Immuno-affinity Purification
Edward Li
Cell Signaling Technology, China & Asia-pacific
4:50- Adjiorn

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